Next-Generation Therapeutic Interventions Driving Regeneration in Diabetic Wound Healing
DOI:
https://doi.org/10.15662/IJRAI.2026.0902005Keywords:
Diabetic wound healing, Regenerative therapeutics, Smart biomaterials, Stem cell based therapies, Gene-editing technologyAbstract
Chronic inflammation, angiogenesis, neuropathy, oxidative stress, and an imbalance of microbes are some of the complications that affect the healing process, hence the challenge in the healing of diabetic wounds across the globe. However, it is not possible to achieve the healing process through the regeneration of tissues using conventional methods. The article highlights the need for regenerative methods rather than the conventional methods of treating the complications that affect the healing process of diabetic wounds, as it is the need of the hour to heal the wounds completely, i.e., both structurally and functionally. New biomaterials, such as smart hydrogels, ECM-mimicking scaffolds, and nanofibers, are some of the regenerative methods that are being adopted in the healing of diabetic wounds. Exosomes and stem cell therapy are also being adopted in the healing of diabetic wounds, as they reduce the level of inflammation and promote angiogenesis in the wound area. Also, the molecular dysfunctions that affect the healing process are being corrected through RNA-based therapy and gene editing tools. Personalized care for the healing of diabetic wounds, as well as the results, are being improved through innovations such as 3D bioprinting, electroceut.
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